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The standard dose of epinephrine for an adult experiencing anaphylaxis is 0.3 to 0.5 mg administered intramuscularly. This method of delivery is preferred because it allows for quicker absorption into the bloodstream, which is vital during an anaphylactic reaction where rapid intervention is necessary to combat severe allergic responses.

Administering the medication intramuscularly, typically into the lateral thigh, ensures that it reaches systemic circulation effectively and provides the desired therapeutic effects, such as bronchodilation and vasoconstriction, which help to alleviate symptoms of anaphylaxis.

In contrast, other routes such as intravenous or subcutaneous administration are less common for initial treatment in the context of anaphylaxis due to variable absorption rates and potential for complications. Intranasal delivery methods are not standard practice for treating anaphylaxis in adults and may not provide the same efficacy as intramuscular injections.